Cannabinoids have generally accepted palliative effects on some symptoms related to cancer of all types; accumulating preclinical data suggest that cannabinoids may reduce tumor growth in animal cancer models. This is achieved by influencing the signaling of specific biochemical pathways, which are involved in controlling the proliferation of cancer cells as well as their survival. Besides, cannabinoids seem to inhibit neo-angiogenesis and reduce the invasiveness of tumors (in animal studies). Human studies of this sort are not available yet. We will here address specifically glioblastoma multiform (GBM), one of the deadliest and most treatment-resistant cancers in humans.
The agnostic’s half-truth busted — An Integrative approach
No funding has been received and there is no conflict of interests
Characteristics of COVID19: Know thy enemy
Clinical & Epidemiologic aspect
The virus-host interaction
Prophylactic measures: A strategy for the reduction of risk
Establishing a strong primary care system
Overview of therapeutic measures
The prevailing treatment
Other treatment options
Immunostimulatory herbal medicines
Treatment considerations for the severely ill
1. Glucocorticoids (GCs)
3. Measures to counter cell-free hemoglobin (CFH) effects
4. Chloroquine & Azithromycin
It turns out that they are equal but different. Why is that?
The use and abuse of cannabis, for medical or other reasons, is undeniably on the rise. As the experience of the medical world with the plant and its products increases, we begin to see a difference that we had not realized before: Cannabis affects men differently from women in some respects. This difference extends to animals as well. It has a biological basis, and it is related to the different effects of hormones on the endocannabinoid system (ECS), a diffuse system consisting of endogenous lipid ligands (endocannabinoids, ECs)…
Can we do better?
According to the WHO, there are nearly 10 million new cases of dementia every year, worldwide. It is estimated that the incidence in the general population aged 60 and over is 5–8%. The WHO recognizes dementia as a public health priority because its frequency is on the rise; it can be overwhelming for the families of affected people; it has significant social and economic implications: The direct and indirect cost of dementia to society is at the order of 1.1% of global GDP (0.2%-1.4% depending on how rich is the country).
A neglected multi-purpose hormone and a simple painkiller in action
What does the “fall-asleep-fast” pill have to do with infections? Well, have you ever heard of off-label uses of medicines? Regulators (the FDA in the US) approve substances for the treatment of specific morbid conditions, and this is what shows on the label. This does not mean that there are no other potential uses, but these unfortunately pass into oblivion until someone bring them back to attention. Similar is the case with acetaminophen (alias paracetamol), well known in the US as Tylenol, whose label reads “anti-pyretic, analgesic”.
Emphasis on immunoregulation: The ECS is a disease modifier
The Endo-Cannabinoid System (ECS) is a disperse system, extending throughout the body; it is in constant interplay with all other organ systems promoting homeostasis in almost every aspect. Despite that, the ECS is still neglected and not included in the curricula of medical schools. For this reason a few introductory notes are in order. The ECS is the regulator of cognition, mood, nociception, energy metabolism, oxidation, inflammatory processes and a disease modifier as well.
The ECS consists of receptors, ligands to these receptors and enzymes that synthesize and degrade these ligands…
Is it ethical not to investigate the use of phytocannabinoids?
I have been very curious to see what experts had to say about cannabis use in the COVID19 epidemic, and thus have been researching extensively. I have found only broad generalizations, along with the popular refrain “cannabidiol does not cure coronavirus”. I find it to be a very over-simplified statement (who is talking about treatment of the virus itself, anyway?) and so I decided to do my own research.
According to all the studies to date (Nichols & Kaplan, 2020), there is no doubt that CBD is immunomodulatory and anti-inflammatory…